Across the globe, the availability of freshwater, both for ecosystems conservation and for meeting people’s needs, is facing a massive crisis. The same is true for the Hindu Kush Himalaya (HKH), or the “Water Tower of Asia”. The HKH is the source of 10 large rivers of Asia, serving the water needs of 16 countries; at least 2 billion people live in these basins. Amidst such huge dependence of both human populations and ecosystems, complex governance challenges have emerged. Today the HKH is a hotspot for water crises and their impacts. As early as in 1992, the idea of Integrated Water Resource Management (IWRM) has been proffered as a strategy for managing water resources in a holistic manner and thereby avoiding resource challenges from escalating into crises. IWRM has remained marginal in its utility, however. This report builds on existing knowledge about integrated governance and offers a framework for bringing IWRM closer to practice. Using the cases of the 10 HKH river basins, this study charts a framework for creating a System of Integrated Knowledge (SINK). The report outlines the steps in the process of integration of knowledge at three levels: primary, secondary, and tertiary. It underlines the need for capacity building for policymakers and practitioners in the governance of the HKH river basins.